Overview

  • Product name
    Anti-C11orf85 antibody
  • Description
    Rabbit polyclonal to C11orf85
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 1 and 176 of Human C11orf85 (NP_001032302)

  • Positive control
    • 293T, A431, HeLa, HepG2, Molt-4 and Raji cells

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab97877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 25 kDa.

Target

  • Function
    Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.
  • Sequence similarities
    Belongs to the MAJIN family.
  • Cellular localization
    Nucleus inner membrane. Chromosome, telomere. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C11orf85 antibody
    • Chromosome 11 open reading frame 85 antibody
    • LOC283129 antibody
    • MAJIN_HUMAN antibody
    • Membrane-anchored junction protein antibody
    • MGC126364 antibody
    see all

Images

  • All lanes : Anti-C11orf85 antibody (ab97877) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 25 kDa

References

ab97877 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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