• Product name
    Anti-C14orf151 antibody
  • Description
    Rabbit polyclonal to C14orf151
  • Tested applications
    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 88-232 of Human C14orf151 (Q27J81).

  • Positive control
    • C14orf151 transfected HEK293T cells, Human stomach tissue, U-251MG cells



Our Abpromise guarantee covers the use of ab121114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.
WB 1/250 - 1/500.
ICC/IF Use a concentration of 1 - 4 µg/ml. The following steps are recommended prior to antibody incubation: cells fixation in ice cold 4% paraformaldehyde pH 7.2-7.3, followed by permeabilization with 0.1% Triton X-100 in PBS for 3x5 minutes.


  • Function
    Severs actin filaments and accelerates their polymerization and depolymerization.
  • Tissue specificity
    Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
  • Involvement in disease
    Defects in INF2 are the cause of focal segmental glomerulosclerosis type 5 (FSGS5) [MIM:613237]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • Sequence similarities
    Belongs to the formin homology family.
    Contains 1 FH2 (formin homology 2) domain.
    Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
    Contains 1 WH2 domain.
  • Domain
    The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers.
    Regulated by autoinhibition due to intramolecular GBD-DAD binding.
    The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus.
  • Cellular localization
    Cytoplasm > perinuclear region.
  • Information by UniProt
  • Database links
  • Alternative names
    • C14orf151 antibody
    • C14orf173 antibody
    • CMTDIE antibody
    • DKFZp762A0214 antibody
    • FLJ22056 antibody
    • FSGS5 antibody
    • HBEAG binding protein 2 binding protein C antibody
    • HBEBP2 binding protein C antibody
    • HBEBP2-binding protein C antibody
    • INF 2 antibody
    • inf2 antibody
    • INF2_HUMAN antibody
    • Inverted formin 2 antibody
    • Inverted formin FH2 and WH2 domain containing antibody
    • Inverted formin-2 antibody
    • MGC13251 antibody
    • pp9484 antibody
    see all

Anti-C14orf151 antibody images

  • All lanes : Anti-C14orf151 antibody (ab121114) at 1/250 dilution

    Lane 1 : vector only transfected HEK293T lysate
    Lane 2 : C14orf151 transfected HEK293T lysate (Co-expressed with a C-terminal myc-DDK tag, ~3.1 kDa)

    Developed using the ECL technique
  • ab121114 at 1/60 dilution staining C14orf151 in Paraffin-emebedded Human stomach tissue by Immunohistochemistry. Note: strong cytoplasmic positivity in glandular cells.
  • Immunofluorescent staining ofC14orf151 in U-251MG cells using ab12114 at a concentration of 4 µg/ml. Note: shows positivity in nucleus & cytoplasm.

References for Anti-C14orf151 antibody (ab121114)

ab121114 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab121114.
Please use the links above to contact us or submit feedback about this product.


Sign up