• Product nameAnti-C19orf2 antibody
    See all C19orf2 primary antibodies
  • Description
    Mouse polyclonal to C19orf2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length C19orf2 protein (Human)

  • Positive control
    • C19orf2 transfected 293T cell lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab67603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: 1/500 - 1/1000. Detects a band of approximately 37 kDa.
    Detection Antibody Pair.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
      Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival sigaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity at mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
    • Tissue specificityUbiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.
    • Sequence similaritiesBelongs to the RNA polymerase II subunit 5-mediating protein family.
    • Post-translational
      Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, releaves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity and preventing sustained S6K1-dependent signaling.
    • Cellular localizationNucleus. Cytoplasm. Mitochondrion. Cell projection > dendrite. Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • C19orf2 antibody
      • Chromosome 19 open reading frame 2 antibody
      • NNX3 antibody
      • NNX3 protein antibody
      • PPP1R19 antibody
      • Protein NNX3 antibody
      • Protein phosphatase 1 regulatory subunit 19 antibody
      • RMP antibody
      • RMP_HUMAN antibody
      • RNA polymerase II subunit 5 mediating protein antibody
      • RNA polymerase II subunit 5-mediating protein antibody
      • RPB5 mediating protein antibody
      • RPB5-mediating protein antibody
      • Unconventional prefoldin RPB5 interactor 1 antibody
      • Unconventional prefoldin RPB5 interactor antibody
      • URI antibody
      • URI1 antibody
      • URI1, prefoldin-like chaperone antibody
      see all

    Anti-C19orf2 antibody images

    • All lanes : Anti-C19orf2 antibody (ab67603) at 1/500 dilution

      Lane 1 : C19orf2 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

    References for Anti-C19orf2 antibody (ab67603)

    ab67603 has not yet been referenced specifically in any publications.

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