Overview

  • Product nameAnti-C1orf77 antibody
    See all C1orf77 primary antibodies
  • Description
    Rabbit polyclonal to C1orf77
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 41-71 of Human C1orf77 (Q9Y3Y2)

  • Positive control
    • 293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab102993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 26 kDa.

Target

  • FunctionPlays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).
    Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939).
  • Tissue specificityExpressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).
  • Post-translational
    modifications
    Asymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5.
  • Cellular localizationNucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332).
  • Information by UniProt
  • Database links
  • Alternative names
    • C1orf77 antibody
    • chromatin target of chromatin target of PRMT1 protein antibody
    • Chromatin target of PRMT1 antibody
    • Chromatin target of PRMT1 protein antibody
    • Chromosome 1 open reading frame 77 antibody
    • CHTOP antibody
    • CHTOP_HUMAN antibody
    • DKFZp547E1010 antibody
    • FL- RP1-178F15.2 antibody
    • FL-SRAG antibody
    • FOP antibody
    • Friend of PRMT1 antibody
    • Friend of PRMT1 protein antibody
    • HT031 antibody
    • MGC131924 antibody
    • MGC86949 antibody
    • OTTHUMP00000035122 antibody
    • OTTHUMP00000035123 antibody
    • Pp7704 antibody
    • RP1 178F15.2 antibody
    • Small arginine- and glycine-rich protein antibody
    • Small protein rich in arginine and glycine antibody
    • SRAG antibody
    • SRAG-3 antibody
    • SRAG-5 antibody
    see all

Anti-C1orf77 antibody images

  • Anti-C1orf77 antibody (ab102993) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size : 26 kDa

References for Anti-C1orf77 antibody (ab102993)

ab102993 has not yet been referenced specifically in any publications.

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