FunctionPlays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939).
Tissue specificityExpressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).
Post-translational modificationsAsymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5.
Cellular localizationNucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332).
chromatin target of chromatin target of PRMT1 protein antibody
Chromatin target of PRMT1 antibody
Chromatin target of PRMT1 protein antibody
Chromosome 1 open reading frame 77 antibody
FL- RP1-178F15.2 antibody
Friend of PRMT1 antibody
Friend of PRMT1 protein antibody
RP1 178F15.2 antibody
Small arginine- and glycine-rich protein antibody
Small protein rich in arginine and glycine antibody
Anti-C1orf77 antibody images
Western blot - Anti-C1orf77 antibody (ab123603)
All lanes : Anti-C1orf77 antibody (ab123603) at 0.4 µg/ml
Lane 1 : Whole cell lysate from Jurkat cells at 50 µg Lane 2 : Whole cell lysate from Jurkat cells at 15 µg Lane 3 : Whole cell lysate from 293T cells at 50 µg Lane 4 : Whole cell lysate from HeLa cells at 50 µg
Developed using the ECL technique
Predicted band size : 26 kDa
Exposure time : 30 seconds
References for Anti-C1orf77 antibody (ab123603)
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