Overview

  • Product nameAnti-C1QA antibody [EPR2979(2)]
    See all C1QA primary antibodies
  • Description
    Rabbit monoclonal [EPR2979(2)] to C1QA
  • Tested applicationsSuitable for: WB, IP, ICCmore details
    Unsuitable for: Flow Cyt or IHC-P
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human C1QA.

  • Positive control
    • Humanplasma and serum lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

  • FormLiquid
  • Storage instructionsFrozen Stock (-20C). Shelf life 12 months.
  • Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • PurityTissue culture supernatant
  • ClonalityMonoclonal
  • Clone numberEPR2979(2)
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab108325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 26 kDa.
IP 1/10 - 1/100.
ICC 1/100 - 1/250.
  • Application notesIs unsuitable for Flow Cyt or IHC-P.
  • Target

    • FunctionC1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
    • Involvement in diseaseDefects in C1QA are the cause of complement component C1qA deficiency (C1QAD) [MIM:120550]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
    • Sequence similaritiesContains 1 C1q domain.
      Contains 1 collagen-like domain.
    • Post-translational
      modifications
      O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • C1qa antibody
      • C1QA_HUMAN antibody
      • Complement C1q subcomponent subunit A antibody
      • Complement component 1 q subcomponent A chain antibody
      • Complement component 1 q subcomponent alpha polypeptide antibody
      • Complement component C1q A chain antibody
      see all

    Anti-C1QA antibody [EPR2979(2)] images

    • All lanes : Anti-C1QA antibody [EPR2979(2)] (ab108325) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Human serum lysates

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 26 kDa

    References for Anti-C1QA antibody [EPR2979(2)] (ab108325)

    ab108325 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab108325.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"