Overview

  • Product nameAnti-C1QC antibody
    See all C1QC primary antibodies
  • Description
    Rabbit polyclonal to C1QC
  • Specificitydetects endogenous levels of total C1QC protein.
  • Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from internal sequence of Human C1QC (UniProt ID: P02747).

  • Positive control
    • Rat lung cell lysate, Human lung carcinoma tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab92689 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
IHC-P
  • Application notesELISA: 1/40000.
    IHC-P: 1/50 - 1/100. Antigen retrieval is not essential but may optimise staining.
    WB: 1/500 - 1/1000. Predicted molecular weight: 26 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionC1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
    • Involvement in diseaseDefects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
    • Sequence similaritiesContains 1 C1q domain.
      Contains 1 collagen-like domain.
    • Post-translational
      modifications
      O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI385742 antibody
      • C1Q C antibody
      • C1qc antibody
      • C1QC_HUMAN antibody
      • C1QG antibody
      • Complement C1q subcomponent subunit C antibody
      • Complement component 1, q subcomponent, C chain antibody
      • complement component 1, q subcomponent, gamma polypeptide antibody
      see all

    Anti-C1QC antibody images

    • All lanes : Anti-C1QC antibody (ab92689) at 1/500 dilution

      Lane 1 : Rat lung cell lysate in absence of blocking peptide
      Lane 2 : Rat lung cell lysate in presence of blocking peptide (10 µg)

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 26 kDa
    • ab92689 at 1/50 dilution staining C1QC in Human lung carcinoma in (1) absence of blocking peptide and (2) presence of blocking peptide by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

    References for Anti-C1QC antibody (ab92689)

    ab92689 has not yet been referenced specifically in any publications.

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"