Overview

  • Product name
  • Description
    Rabbit polyclonal to C1QC
  • Specificity
    detects endogenous levels of total C1QC protein.
  • Tested applications
    Suitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from internal sequence of Human C1QC (UniProt ID: P02747).

  • Positive control
    • Rat lung cell lysate, Human lung carcinoma tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab92689 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
IHC-P
  • Application notes
    ELISA: 1/40000.
    IHC-P: 1/50 - 1/100. Antigen retrieval is not essential but may optimise staining.
    WB: 1/500 - 1/1000. Predicted molecular weight: 26 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
    • Involvement in disease
      Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
    • Sequence similarities
      Contains 1 C1q domain.
      Contains 1 collagen-like domain.
    • Post-translational
      modifications
      O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI385742 antibody
      • C1Q C antibody
      • C1qc antibody
      • C1QC_HUMAN antibody
      • C1QG antibody
      • Complement C1q subcomponent subunit C antibody
      • Complement component 1, q subcomponent, C chain antibody
      • complement component 1, q subcomponent, gamma polypeptide antibody
      see all

    Images

    • All lanes : Anti-C1QC antibody (ab92689) at 1/500 dilution

      Lane 1 : Rat lung cell lysate in absence of blocking peptide
      Lane 2 : Rat lung cell lysate in presence of blocking peptide (10 µg)

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 26 kDa
    • ab92689 at 1/50 dilution staining C1QC in Human lung carcinoma in (1) absence of blocking peptide and (2) presence of blocking peptide by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

    References

    ab92689 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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