Overview

  • Product nameAnti-C1s antibody [49]
    See all C1s primary antibodies
  • Description
    Mouse monoclonal [49] to C1s
  • SpecificityThis antibody is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Human C1s.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.097% Sodium azide
    Constituents: PBS, 2.9% Sodium chloride
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • Clone number49
  • MyelomaSp2
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab17192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • FunctionC1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
  • Involvement in diseaseDefects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 CUB domains.
    Contains 1 EGF-like domain.
    Contains 1 peptidase S1 domain.
    Contains 2 Sushi (CCP/SCR) domains.
  • Post-translational
    modifications
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Information by UniProt
  • Database links
  • Alternative names
    • Basic proline rich peptide IB 1 antibody
    • C1 esterase antibody
    • C1S antibody
    • C1S_HUMAN antibody
    • Complement C1s subcomponent antibody
    • Complement C1s subcomponent heavy chain antibody
    • Complement C1s subcomponent light chain antibody
    • Complement component 1 s subcomponent antibody
    • Complement component 1 subcomponent s antibody
    • FLJ44757 antibody
    see all

References for Anti-C1s antibody [49] (ab17192)

ab17192 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"