• Product nameAnti-C1s antibody
    See all C1s primary antibodies
  • Description
    Rabbit polyclonal to C1s
  • Specificityab72651 detects endogenous levels of fragment of activated C1s resulting from cleavage adjacent to Arg437.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from human C1s.

  • Positive control
    • Extracts from 293 cells treated with etoposide (25uM, 1hour) and HeLa cells treated with etoposide (25uM, 24hours).


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab72651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: 1/20000.
    WB: 1/500 - 1/1000. Detects bands of approximately 75 & 51 kDa (predicted molecular weight: 77 & 51 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionC1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
    • Involvement in diseaseDefects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
    • Sequence similaritiesBelongs to the peptidase S1 family.
      Contains 2 CUB domains.
      Contains 1 EGF-like domain.
      Contains 1 peptidase S1 domain.
      Contains 2 Sushi (CCP/SCR) domains.
    • Post-translational
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • Information by UniProt
    • Database links
    • Alternative names
      • Basic proline rich peptide IB 1 antibody
      • C1 esterase antibody
      • C1S antibody
      • C1S_HUMAN antibody
      • Complement C1s subcomponent antibody
      • Complement C1s subcomponent heavy chain antibody
      • Complement C1s subcomponent light chain antibody
      • Complement component 1 s subcomponent antibody
      • Complement component 1 subcomponent s antibody
      • FLJ44757 antibody
      see all

    Anti-C1s antibody images

    • All lanes : Anti-C1s antibody (ab72651) at 1/500 dilution

      Lane 1 : Extracts from 293 cells treated with etoposide (25uM, 1hour)
      Lane 2 : Extracts from HeLa cells treated with etoposide (25uM, 24hours)
      Lane 3 : Extracts from HeLa cells treated with etoposide (25uM, 24hours) with Cl-peptide at 5 µg

      Lysates/proteins at 5 µg per lane.

      Predicted band size : 77 , 51 kDa
      Observed band size : 51,75 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 22 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-C1s antibody (ab72651)

    ab72651 has not yet been referenced specifically in any publications.

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