For the best experience on the Abcam website please upgrade to a modern browser such as
Product name Anti-C1s antibody See all C1s primary antibodies
Rabbit polyclonal to C1s
Tested applications Suitable for:
ELISA, WB, IHC-P more details
Synthetic peptide derived from a region corresponding to internal residues of Human C1s
COLO, Jurkat cells and Human breast carcinoma tissue
Storage instructions Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage buffer Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg 2+ and Ca 2+),150mM Sodium chloride, pH 7.4
Concentration information loading...
Purity Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes ELISA: 1/40000.
IHC-P: 1/50 - 1/100.
WB: 1/500 - 1/1000. Predicted molecular weight: 77 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Function C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
Involvement in disease Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Sequence similarities Belongs to the peptidase S1 family. Contains 2 CUB domains. Contains 1 EGF-like domain. Contains 1 peptidase S1 domain. Contains 2 Sushi (CCP/SCR) domains.
Post-translational modifications The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Information by UniProt
Basic proline rich peptide IB 1 antibody
C1 esterase antibody
Anti-C1s antibody images
Western blot - C1s antibody (ab92706)
All lanes : Anti-C1s antibody (ab92706) at 1/500 dilution Lane 1 : COLO cells
(without peptide) Lane 2 : Jurkat cells
(without peptide) Lane 3 : COLO cells
(with peptide) Lysates/proteins at 30 µg per lane. Predicted band size : 77 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - C1s antibody (ab92706)
ab92706 at 1/50 dilution, staining C1s in Human breast carcinoma paraffin-embedded tissue by immunohistochemistry. Right hand image with peptide and left hand image without peptide.
References for Anti-C1s antibody (ab92706)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"