• Product nameAnti-C2 antibody [6E3]
    See all C2 primary antibodies
  • Description
    Mouse monoclonal [6E3] to C2
  • SpecificityStrong reaction is seen with human serum/plasma and no reaction is seen with serum from patients deficient in C2. ab17452 reacts with C2 and a subfraction of C2 believed to be C2b.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native complement component C2 protein, isolated from human plasma.

  • EpitopeEpitope specificity differs from that of ab17451 as determined by inhibition ELISA.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone number6E3
  • Myelomax63-Ag8.653
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas


Our Abpromise guarantee covers the use of ab17452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: 1/500.
    WB: 1/250. Predicted molecular weight: 102 kDa. ab17452 reacts with C2 under reducing and non-reducing conditions.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
    • Involvement in diseaseDefects in C2 are the cause of complement component 2 deficiency (C2D) [MIM:217000]. A deficiency of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent or invasive infections.
    • Sequence similaritiesBelongs to the peptidase S1 family.
      Contains 1 peptidase S1 domain.
      Contains 3 Sushi (CCP/SCR) domains.
      Contains 1 VWFA domain.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • ARMD14 antibody
      • C2 antibody
      • C3/C5 convertase antibody
      • CO2 antibody
      • CO2_HUMAN antibody
      • Complement C2 antibody
      • Complement C2a fragment antibody
      • complement component 2 antibody
      • DKFZp779M0311 antibody
      see all

    References for Anti-C2 antibody [6E3] (ab17452)

    This product has been referenced in:
    • Martini PG  et al. Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases. BMC Immunol 11:43 (2010). Sandwich ELISA ; Human . Read more (PubMed: 20727163) »

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry. I received the following information from the originator of these two antibodies: "The protocol we used to test these antibodies was a direct ELISA with a coat of C2, a layer with ab17451 (1:6500) or ab17452 (1:500), and det...

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