Overview

  • Product nameAnti-C20orf77 antibody
    See all C20orf77 primary antibodies
  • Description
    Rabbit polyclonal to C20orf77
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 143-192 (KKSLKRTFQQ IQEEEDDDYP GSYSPQDPSA GPLLTEELIK ALQDLENAAS) of Human C20orf77 (NP_067038).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab104222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceC20orf77 interacts with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. It is a transcriptional regulator which enhances expression of CCND1. It promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. It also revents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • C20orf77 antibody
    • Cell cycle related and expression elevated protein in tumor antibody
    • Chromosome 20 open reading frame 77 antibody
    • CREPT antibody
    • dJ1057B20.2 antibody
    • DKFZp434P0735 antibody
    • FLJ44520 antibody
    • Hypothetical protein LOC58490 antibody
    • NET60 antibody
    • Regulation of nuclear pre mRNA domain containing 1B antibody
    • Regulation of nuclear pre mRNA domain containing protein 1B antibody
    • Uncharacterized protein C20orf77 antibody
    see all

Anti-C20orf77 antibody images

  • Anti-C20orf77 antibody (ab104222) at 1 µg/ml (Anti-RPRD1B Antibody) + Jurkat cell lysate

    Predicted band size : 37 kDa

References for Anti-C20orf77 antibody (ab104222)

ab104222 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"