Overview

  • Product name
  • Description
    Chicken polyclonal to C3IP1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Xenopus laevis
  • Immunogen

    Synthetic peptide:

    KHAKKEREES LPNLLQYVRM PLLTPRYITD VIDAEPFIRC SLQCRDLVDE AKKFHLRPEL RSQMQGPRTR ARLGANEVLL VVGGFGSQQS PIDVVEKYDP KTQEWSFLPS ITRKRRYVAS VSLHDRIYVI GGYDGRSRLS SVECLDYTAD EDGVWYSVAP MNVRRGLAGA TTLGDMIYVS GGFDGSRRHT SMERYDPNID

    , corresponding to amino acids 205-404 of Human C3IP1.

Properties

Applications

Our Abpromise guarantee covers the use of ab14233 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 68 kDa.

Target

  • Function
    Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
  • Tissue specificity
    Highly expressed in testis and at lower levels in the submandibular salivary gland.
  • Sequence similarities
    Contains 1 BTB (POZ) domain.
    Contains 6 Kelch repeats.
  • Domain
    The BTB domain is required for interaction with CUL3.
  • Information by UniProt
  • Database links
  • Alternative names
    • C3IP1 antibody
    • CUL3 interacting protein 1 antibody
    • CUL3-interacting protein 1 antibody
    • DKIR antibody
    • DKIR homolog antibody
    • FLJ27152 antibody
    • hDKIR antibody
    • Kelch like 12 (Drosophila) antibody
    • Kelch like 12 antibody
    • Kelch like 12 variant antibody
    • Kelch like protein 12 antibody
    • Kelch like protein C3IP1 antibody
    • kelch-like family member 12 antibody
    • Kelch-like protein 12 antibody
    • KLH12_HUMAN antibody
    • KLHL 12 antibody
    • klhl12 antibody
    • OTTHUMP00000038799 antibody
    see all

Images



  • Predicted band size : 68 kDa


    Western Blot analysis of an E. coli derived fusion protein (C3IP1 N-205 fusion protein) using ab14233 at a 1/2000 dilution.

References

This product has been referenced in:
  • Angers S  et al. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol 8:348-57 (2006). Chicken . Read more (PubMed: 16547521) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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