Anti-C4 binding protein antibody [10-07] (ab118876)

Overview

  • Product nameAnti-C4 binding protein antibody [10-07]
    See all C4 binding protein primary antibodies
  • Description
    Mouse monoclonal [10-07] to C4 binding protein
  • Specificityab118876 recognizes complement C4 binding protein.
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native Human C4 binding protein (purified).

  • Positive control
    • Human liver tissue
  • General notes


    There are three variants of C4 binding protein, composed of alpha and beta chains. The predominant form is a 570 kD complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kD homoheptamer of alpha chains or a 500 kD complex of 6 alpha chains and 1 beta chain. C4 binding protein is expressed in the blood serum.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 8.40
    Preservative: 0.1% Sodium azide
    Constituent: 99% Borate buffered saline
  • Concentration information loading...
  • PurityProtein A purified
  • Primary antibody notesThere are three variants of C4 binding protein, composed of alpha and beta chains. The predominant form is a 570 kD complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kD homoheptamer of alpha chains or a 500 kD complex of 6 alpha chains and 1 beta chain. C4 binding protein is expressed in the blood serum.
  • ClonalityMonoclonal
  • Clone number10-07
  • IsotypeIgG2b
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab118876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionControls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
  • Sequence similaritiesContains 3 Sushi (CCP/SCR) domains.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • C4b binding protein beta chain antibody
    • C4b-binding protein beta chain antibody
    • C4BP antibody
    • C4BPB antibody
    • C4BPB_HUMAN antibody
    • Complement component 4 binding protein beta antibody
    • Complement component 4 binding protein beta chain antibody
    • Complement component 4-binding protein beta antibody
    • OTTHUMP00000034288 antibody
    • OTTHUMP00000034289 antibody
    • OTTHUMP00000034375 antibody
    • OTTHUMP0000003474 antibody
    • Proline rich protein antibody
    • PRP antibody
    see all

Anti-C4 binding protein antibody [10-07] images

  • ab118876, at 5 µg/ml, staining C4 binding protein in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry.

References for Anti-C4 binding protein antibody [10-07] (ab118876)

ab118876 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"