Overview

  • Product name
  • Description
    Chicken polyclonal to C4A
  • Specificity
    ab61965 gives only one precipitin arc in immunodiffusion against normal human serum or human C4. It reacts with alpha and beta chains in electroblotting.
  • Tested applications
    Suitable for: Immunodiffusion, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    full lenth native protein C4A (SwissProt P0C0L4) purified from human plasma.

  • Positive control
    • Human serum.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.1% Sodium Azide
    Constituents: 0.9% Sodium chloride
  • Concentration information loading...
  • Purity
    IgY fraction
  • Clonality
    Polyclonal
  • Isotype
    IgY
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab61965 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Immunodiffusion Use a concentration of 1 - 3 mg/ml.
WB Use a concentration of 1 - 3 mg/ml. Predicted molecular weight: 35 kDa.

Target

  • Relevance
    C4A is the acidic form of complement factor 4, part of the classical activation pathway. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
  • Cellular localization
    Secreted
  • Database links
  • Alternative names
    • Acidic C4 antibody
    • Acidic complement C4 antibody
    • C3 and PZP like alpha 2 macroglobulin domain containing protein 2 antibody
    • C4 antibody
    • C4A anaphylatoxin antibody
    • C4A antibody
    • C4A2 antibody
    • C4A3 antibody
    • C4A4 antibody
    • C4A6 antibody
    • C4AD antibody
    • C4S antibody
    • CO4 antibody
    • Complement C4-A antibody
    • Complement component 4A antibody
    • Complement component 4A (Rodgers blood group) antibody
    • CPAMD2 antibody
    • RG antibody
    • Rodgers blood group antibody
    • Rodgers form of C4 antibody
    see all

References

ab61965 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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