Anti-C5 / C5a antibody (ab46168)

Overview

• Product nameAnti-C5 / C5a antibody
  See all C5 / C5a primary antibodies
• Description
  Rabbit polyclonal to C5 / C5a
• Tested applicationsSuitable for: WBmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic peptide corresponding to Human C5/ C5a aa 1450-1550 conjugated to Keyhole Limpet Haemocyanin (KLH).
  (Peptide available as ab46167)

• Positive control
  • This antibody gave a positive signal in purified human Complement C5 protein.
• General notes

  
  

  This antibody binds specifically to the alpha / alpha' chain of C5, which forms part of C5b

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Primary antibody notesThis antibody binds specifically to the alpha / alpha' chain of C5, which forms part of C5b
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

  • Immunology
  • Innate Immunity
  • Complement
  • MAC

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • MAPK Pathway

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • GPCR

  • Cell Biology
  • Other Antibodies
  • Oxidative Stress

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunizing Peptide (Blocking)
  • C5 / C5b peptide (ab46167)

Applications

Target

• FunctionActivation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
  Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
• Involvement in diseaseComplement component 5 deficiency
  An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
• Sequence similaritiesContains 1 anaphylatoxin-like domain.
  Contains 1 NTR domain.
• Cellular localizationSecreted.

• Target information above from: UniProt accession P01031 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 727 Human
  • Entrez Gene: 15139 Mouse
  • Omim: 120900 Human
  • SwissProt: P01031 Human
  • SwissProt: P06684 Mouse
  • Unigene: 494997 Human
  • Unigene: 2168 Mouse
• Alternative names
  • Anaphylatoxin C5a analog antibody
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody
  • C5 antibody

  • C5a antibody
  • CO5_HUMAN antibody
  • Complement C5 alpha'' chain antibody
  • Complement C5 antibody
  • Complement component C5 antibody
  • CPAMD4 antibody

  see all