Overview

  • Product name
    Anti-C5R1 antibody [10/92] (Biotin)
    See all C5R1 primary antibodies
  • Description
    Rat monoclonal [10/92] to C5R1 (Biotin)
  • Conjugation
    Biotin
  • Specificity
    Clone 10/92 does not block the binding of the C5a to murine CD88.
  • Tested applications
    Suitable for: Flow Cyt, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    RBL-2H3 transfected cells expressing murine C5R1.

Properties

Applications

Our Abpromise guarantee covers the use of ab54378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/1. ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.

Target

  • Function
    Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANAPHYLATOXIN RECEPTOR antibody
    • C5a anaphylatoxin chemotactic receptor antibody
    • C5a anaphylatoxin receptor antibody
    • C5A antibody
    • C5a ligand antibody
    • C5a-R antibody
    • C5aR antibody
    • C5AR_HUMAN antibody
    • c5ar1 antibody
    • C5R1 antibody
    • CD88 antibody
    • CD88 antigen antibody
    • Complement component 5 receptor 1 antibody
    • Complement component 5 receptor 2 antibody
    • Complement component 5a receptor 1 antibody
    see all

References

This product has been referenced in:
  • Copland DA  et al. Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis. Clin Exp Immunol 159:303-14 (2010). IHC-Fr ; Mouse . Read more (PubMed: 20002447) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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