Overview

  • Product name
    Anti-C6 antibody [13H5]
    See all C6 primary antibodies
  • Description
    Mouse monoclonal [13H5] to C6
  • Tested applications
    Suitable for: WB, IP, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    C6 protein purified from human plasma.

  • Positive control
    • Human plasma

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.03% Sodium Azide
    Constituents: 50% Glycerol, 0.01% BSA, HEPES, 0.15M Sodium chloride
  • Concentration information loading...
  • Clonality
    Monoclonal
  • Clone number
    13H5
  • Isotype
    IgG2b
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab71942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
ELISA
  • Application notes
    ELISA: Use at an assay dependent dilution.
    IP: Use 2µl.
    WB: 1/2000. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
    • Involvement in disease
      Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
    • Sequence similarities
      Belongs to the complement C6/C7/C8/C9 family.
      Contains 1 EGF-like domain.
      Contains 2 Kazal-like domains.
      Contains 1 LDL-receptor class A domain.
      Contains 1 MACPF domain.
      Contains 2 Sushi (CCP/SCR) domains.
      Contains 3 TSP type-1 domains.
    • Post-translational
      modifications
      All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • AW111623 antibody
      • C6 antibody
      • CO6_HUMAN antibody
      • Complement component 6 antibody
      • Complement component C6 antibody
      see all

    Anti-C6 antibody [13H5] images

    • All lanes : Anti-C6 antibody [13H5] (ab71942) at 1/2000 dilution

      Lane 1 : C6 protein isolated from human plasma
      Lane 2 : Human plasma at 0.5 µl


      Predicted band size : 105 kDa
      Observed band size : 105 kDa

    References for Anti-C6 antibody [13H5] (ab71942)

    This product has been referenced in:

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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