Overview

  • Product name
    Anti-C6 antibody [8G7]
    See all C6 primary antibodies
  • Description
    Mouse monoclonal [8G7] to C6
  • Tested applications
    Suitable for: ChIP, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    C6 protein purified from human plasma.

  • Positive control
    • Human plasma
  • General notes

    This product was changed from ascites to tissue culture supernatant on 18th September 2017. Lot numbers higher than 690736 will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.03% Sodium Azide
    Constituents: 50% Glycerol, 0.01% BSA, HEPES, 0.15M Sodium chloride
  • Purity
    Tissue culture supernatant
  • Clonality
    Monoclonal
  • Clone number
    8G7
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab71941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ChIP Use at an assay dependent concentration.
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa).

Target

  • Function
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
  • Involvement in disease
    Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
  • Sequence similarities
    Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 2 Kazal-like domains.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 Sushi (CCP/SCR) domains.
    Contains 3 TSP type-1 domains.
  • Post-translational
    modifications
    All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • AW111623 antibody
    • C6 antibody
    • CO6_HUMAN antibody
    • Complement component 6 antibody
    • Complement component C6 antibody
    see all

Anti-C6 antibody [8G7] images

  • All lanes : Anti-C6 antibody [8G7] (ab71941) at 1/5000 dilution

    Lane 1 : C6 protein isolated from human plasma
    Lane 2 : Human plasma at 0.5 µl


    Predicted band size : 105 kDa
    Observed band size : 105 kDa
    Additional bands at : 62 kDa. We are unsure as to the identity of these extra bands.

References for Anti-C6 antibody [8G7] (ab71941)

ab71941 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71941.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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