Overview

  • Product nameAnti-C6 antibody [8G7]
    See all C6 primary antibodies
  • Description
    Mouse monoclonal [8G7] to C6
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    C6 protein purified from human plasma.

  • Positive control
    • Human plasma

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.03% Sodium Azide
    Constituents: 50% Glycerol, 0.01% BSA, HEPES, 0.15M Sodium chloride
  • Concentration information loading...
  • ClonalityMonoclonal
  • Clone number8G7
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab71941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa).

Target

  • FunctionConstituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
  • Involvement in diseaseDefects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
  • Sequence similaritiesBelongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 2 Kazal-like domains.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 Sushi (CCP/SCR) domains.
    Contains 3 TSP type-1 domains.
  • Post-translational
    modifications
    All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • AW111623 antibody
    • C6 antibody
    • CO6_HUMAN antibody
    • Complement component 6 antibody
    • Complement component C6 antibody
    see all

Anti-C6 antibody [8G7] images

  • All lanes : Anti-C6 antibody [8G7] (ab71941) at 1/5000 dilution

    Lane 1 : C6 protein isolated from human plasma
    Lane 2 : Human plasma at 0.5 µl


    Predicted band size : 105 kDa
    Observed band size : 105 kDa
    Additional bands at : 62 kDa. We are unsure as to the identity of these extra bands.

References for Anti-C6 antibody [8G7] (ab71941)

ab71941 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"