Overview

  • Product name
  • Description
    Rabbit polyclonal to C6orf150
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 273-303 of Human C6orf150 (NP_612450.2)

  • Positive control
    • MDA-MB231 cell line lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab106985 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 59 kDa.

Target

  • Function
    Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
  • Tissue specificity
    Expressed in the monocytic cell line THP1.
  • Sequence similarities
    Belongs to the mab-21 family.
  • Cellular localization
    Cytoplasm > cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • C6orf150 antibody
    • cGAMP synthase antibody
    • cGAS antibody
    • CGAS_HUMAN antibody
    • cGMP Synthase antibody
    • Chromosome 6 open reading frame 150 antibody
    • Cyclic GMP-AMP synthase antibody
    • h-cGAS antibody
    • Hypothetical protein LOC115004 antibody
    • Mab 21 domain containing 1 antibody
    • Mab-21 domain-containing protein 1 antibody
    • MB21D1 antibody
    • MGC131892 antibody
    • MGC142166 antibody
    • MGC142168 antibody
    • OTTHUMP00000016743 antibody
    • OTTHUMP00000039330 antibody
    • protein MB21D1 antibody
    • Uncharacterized protein C6orf150 antibody
    see all

Images

  • Anti-C6orf150 antibody (ab106985) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

    Predicted band size : 59 kDa

References

ab106985 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab106985.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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