Overview

  • Product name
    C8N6-BPA (aqueous solution)
  • Description
    Cell-permeable, fast acting, selective lamellipodial growth promoter; branched polymamine
  • Alternative names
    • Lamellipodial Growth Promoter
  • Biological description

    Cell-permeable, fast acting branched polymamine; selectively induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactor by slowing down the actin assembly/disassembly cycle and facilitating nucleation. Has no effect when cellular actin polymerization is prevented by prior incubation with the depolymerizing drugs Cytochalasin D or Latrunculin A.

Properties

  • Chemical name
    N1,N1,N8,N8-Tetrakis(3-aminopropyl)-1,8-octanediamine hydrochloride
  • Molecular weight
    591.40
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H48N6.6HCl
  • CAS Number
    870086-86-5
  • Storage instructions
    Shipped at room temperature. Store at -20°C.
  • Solubility overview
    Supplied in Water (30mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Cl.Cl.Cl.Cl.Cl.Cl.NCCCN(CCCN)CCCCCCCCN(CCCN)CCCN
  • Source

    Synthetic

References

This product has been referenced in:
  • Riveline D  et al. Synthetic polyamines: new compounds specific to actin dynamics for mammalian cell and fission yeast. Bioarchitecture 4:144-8 (2014). Read more (PubMed: 25664996) »
  • Nedeva I  et al. Synthetic polyamines promote rapid lamellipodial growth by regulating actin dynamics. Nat Commun 4:2165 (2013). Read more (PubMed: 23893126) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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