Overview

  • Product nameAnti-C9 antibody [aE11]
    See all C9 primary antibodies
  • Description
    Mouse monoclonal [aE11] to C9
  • Tested applicationsSuitable for: ELISA, IHC-P, IHC-Fr, Flow Cyt, Functional Studiesmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Horse, Human, Pig
  • Immunogen

    Human purified MAC (membrane attack complex)

  • Positive control
    • Mucosa from patients with H. Pylori.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesab90801 was filtered through a 0.2 µm filter.
  • ClonalityMonoclonal
  • Clone numberaE11
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
IHC-P 1/50.
IHC-Fr 1/50.
Flow Cyt 1/50. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
Functional Studies Use at an assay dependent concentration. aE11 inhibits platelet activation by antiphospholipid antibody serum.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionConstituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
    • Tissue specificityPlasma.
    • Involvement in diseaseDefects in C9 are a cause of complement component 9 deficiency (C9D) [MIM:613825]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
    • Sequence similaritiesBelongs to the complement C6/C7/C8/C9 family.
      Contains 1 EGF-like domain.
      Contains 1 LDL-receptor class A domain.
      Contains 1 MACPF domain.
      Contains 1 TSP type-1 domain.
    • Post-translational
      modifications
      Thrombin cleaves factor C9 to produce C9a and C9b.
      Phosphorylation sites are present in the extracelllular medium.
    • Cellular localizationSecreted. Cell membrane. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
    • Information by UniProt
    • Database links
    • Alternative names
      • C9 antibody
      • C9 deficiency antibody
      • C9 deficiency with dermatomyositis antibody
      • CO9_HUMAN antibody
      • Complement component 9 antibody
      • Complement component 9 deficiency antibody
      • Complement component C9 antibody
      • Complement component C9b antibody
      see all

    References for Anti-C9 antibody [aE11] (ab90801)

    This product has been referenced in:
    • Meuwissen M  et al. Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction. J Clin Pathol 59:196-201 (2006). IHC-Fr ; Human . Read more (PubMed: 16443738) »
    • Berstad AE  et al. Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis. Gut 40:196-203 (1997). IHC-P, IF ; Human . Read more (PubMed: 9071931) »

    See all 5 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab90801.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"