![Western blot - cIAP2 antibody [E40] (ab32059) image](#ab32059_1.jpg)
![Immunohistochemistry (Paraffin-embedded sections) - cIAP2 antibody [E40] (ab32059) image](#ab32059_2.jpg)
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Products:Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs
Overview
Product name
Anti-cIAP2 antibody [E40]
See all cIAP2 products (6) ...
Description
Rabbit monoclonal [E40] to cIAP2
Specificity
This antibody is specific for human cIAP2. It does not cross-react with any other IAP family members.
Tested applications
WB, IHC-P, ICC, IPmore details
Cross reactivity
Reacts with
Human
Does not react with
Mouse, Rat
Immunogen
Synthetic peptide corresponding to the residues before the breakpoint for translocation to form BIRC3-MALT1 of Human cIAP2.
Positive control
Daudi cell lysate
General notes
Produced under U.S. Patent No. 5,675,063.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 40% Glycerol, 0.05% BSA, 0.15M Sodium chloride, 50mM Tris glycine. pH 7.4
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
E40
Isotype
IgG
Research areas
Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> IAPs
Cancer >> Invasion/microenvironment >> Apoptosis >> Caspases
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs
Applications
Show applications key
Our Abpromise guarantee covers the use of ab32059 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes
ICC: 1/100.
IHC-P: 1/50.
IP: 1/50.
WB: 1/1000. Predicted molecular weight: 72 kDa.
Is unsuitable for FACS.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).
Tissue specificity
Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Involvement in disease
Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
Sequence similarities
Belongs to the IAP family.
Contains 3 BIR repeats.
Contains 1 CARD domain.
Contains 1 RING-type zinc finger.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ13489
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CIAP 2 antibody
- Inhibitor of apoptosis protein 1 antibody
- AIP 1 antibody
see all
Database links
- Entrez Gene: 330 Human
- Omim: 601721 Human
- SwissProt: Q13489 Human
- Unigene: 127799 Human
Anti-cIAP2 antibody [E40] images:
Western blot - cIAP2 antibody [E40] (ab32059)
![Western blot - cIAP2 antibody [E40] (ab32059)](/ps/datasheet/Images/32/ab32059/ab32059_1.jpg)
Anti-cIAP2 antibody [E40] (ab32059) at 1/1000 dilution + Daudi cell lysate.
Predicted band size : 72 kDa
Observed band size : 72 kDa
Immunohistochemistry (Paraffin-embedded sections) - cIAP2 antibody [E40] (ab32059)
![Immunohistochemistry (Paraffin-embedded sections) - cIAP2 antibody [E40] (ab32059)](/ps/datasheet/Images/32/ab32059/ab32059_2.jpg)
ab32059 at a 1:50 dilution staining cIAP2 in human normal spleen, using Immunohistochemistry, Paraffin Embedded Tissue.
References for Anti-cIAP2 antibody [E40] (ab32059)
This product has been referenced in:
- Juvekar Aet al. Bortezomib Induces Nuclear Translocation of I{kappa}B{alpha} Resulting in Gene-Specific Suppression of NF-{kappa}B-Dependent Transcription and Induction of Apoptosis in CTCL. Mol Cancer Res 9:183-94 (2011). WB; Human.Read more (PubMed: 21224428) »
- Seitz Vet al. Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma. PLoS One 6:e26837 (2011). WB; Human.Read more (PubMed: 22102868) »
See all 4 publications for this product
Publishing research using ab32059? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"