cIAP2 antibody (ab2540)

Product Name 

cIAP2 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to cIAP2

Immunogen 

Available on request.
(Peptide available as ab38273.)

Reacts with 

Hu

Does not react with 
(species key)

Ms

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
WB: Use at a concentration of 1 - 3 µg/ml.

In Western blot, this antibody detects a band of approximately 68 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cytoplasmic

Research areas 

Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> IAPs
Cancer >> Invasion/microenvironment >> Apoptosis >> Caspases
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs

Relevance 

cIAP2 is an apoptotic suppressor. Apoptosis is triggered by a variety of stimuli including members of the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of cIAP (cIAP1 and cIAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The cIAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF alpha by its receptor. Omi, a negative regulator of cIAP, inhibits its activity by catalytically cleaving cIAP. Another negative regulator, Smac/DIABLO, acts by enhancing the autoubiquitization activity of cIAP.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

PBS with 1 mg/ml BSA, 1.5 mM sodium azide and 50% glycerol

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

References for cIAP2 antibody (ab2540)

  This product has been used in: (two most recent references)

Lopergolo A et al. Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation. Br J Cancer 100:739-46 (2009). WB; Mouse. PubMed: 19223905

Esposito I et al. Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer. J Clin Pathol 60:885-95 (2007). PubMed: 16775116

See all 4 publication references for this product.


If you publish research using ab2540 please let us know so that we can cite the reference on this datasheet.

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