Anti-CABP antibody - Carboxyterminal end (ab75949)

Overview

  • Product nameAnti-CABP antibody - Carboxyterminal end
    See all CABP primary antibodies
  • Description
    Rabbit polyclonal to CABP - Carboxyterminal end
  • Tested applicationsSuitable for: IHC-P, WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Positive control
    • Mouse cerebellum tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab75949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.
WB 1/50 - 1/100. Predicted molecular weight: 26 kDa.
ELISA 1/1000.

Target

  • FunctionModulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration.
  • Tissue specificityRetina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
  • Sequence similaritiesContains 4 EF-hand domains.
  • DomainEF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.
  • Post-translational
    modifications
    Phosphorylated. The phosphorylation regulates the activity.
  • Cellular localizationCytoplasm > cell cortex. Cell membrane. S-CaBP1 is localized at or near the plasma membrane; Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cell membrane. Golgi apparatus. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane and Cytoplasm > cytoskeleton. L-CaBP1 is associated most likely with the cytoskeletal structures.
  • Information by UniProt
  • Database links
  • Alternative names
    • CABP 1 antibody
    • CaBP1 antibody
    • CABP1_HUMAN antibody
    • Calbrain antibody
    • Calcium binding protein 1 antibody
    • Calcium binding protein 5 antibody
    • Calcium-binding protein 1 antibody
    • Caldendrin antibody
    • HCALB BR antibody
    • HCALB_BR antibody
    see all

Anti-CABP antibody - Carboxyterminal end images

  • Anti-CABP antibody - Carboxyterminal end (ab75949) at 1/60 dilution + mouse cerebellum tissue lysate at 35 µg

    Predicted band size : 26 kDa
    Observed band size : 26 kDa
  • ab75949 at 1/50 dilution staining CABP - Carboxyterminal in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

References for Anti-CABP antibody - Carboxyterminal end (ab75949)

ab75949 has not yet been referenced specifically in any publications.

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