The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Predicted molecular weight: 30 kDa.
Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages.
Expressed in retina and in the inner hair cells (IHC) of the cochlea.
Involvement in disease
Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B) [MIM:610427]. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
Contains 4 EF-hand domains.
Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity.
Cytoplasm. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.