Overview

  • Product name
    Anti-CABP4 antibody
  • Description
    Rabbit polyclonal to CABP4
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human CABP4.
    Database link: P57796

  • Positive control
    • HeLa, sp2/0 and PC12 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab192367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 30 kDa.

Target

  • Function
    Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages.
  • Tissue specificity
    Expressed in retina and in the inner hair cells (IHC) of the cochlea.
  • Involvement in disease
    Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B) [MIM:610427]. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
  • Sequence similarities
    Contains 4 EF-hand domains.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity.
  • Cellular localization
    Cytoplasm. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.
  • Information by UniProt
  • Database links
    • Alternative names
      • CABP 4 antibody
      • CaBP4 antibody
      • CABP4_HUMAN antibody
      • Calcium binding protein 4 antibody
      • Calcium-binding protein 4 antibody
      • CSNB 2B antibody
      • CSNB2B antibody
      see all

    Images

    • Western blot - Anti-CABP4 antibody (ab192367)
      Western blot - Anti-CABP4 antibody (ab192367)
      All lanes : Anti-CABP4 antibody (ab192367)

      Lane 1 : HeLa whole cell lysate
      Lane 2 : sp2/0 whole cell lysate
      Lane 3 : PC12 whole cell lysate

      Predicted band size: 30 kDa

    References

    ab192367 has not yet been referenced specifically in any publications.

    Publishing research using ab192367? Please let us know so that we can cite the reference in this datasheet.

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