• Product nameAnti-CACNA1H antibody [S55-10]
    See all CACNA1H primary antibodies
  • Description
    Mouse monoclonal [S55-10] to CACNA1H
  • SpecificityNo cross-reactivity against Cav1.3 and Cav3.1
  • Tested applicationsSuitable for: IP, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Fusion protein, corresponding to amino acids 1019-1293 (II-III loop) of Human CACNA1H (accession number O95180)

  • Positive control
    • HEK cell lysate expressing Cav3.2



Our Abpromise guarantee covers the use of ab84815 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesICC/IF: Use at a concentration of 0.1 - 1 µg/ml. (Perox), 1 - 10 µg/ml (IF).
    IP: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 10 µg/ml. Detects a band of approximately 260 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
    • Tissue specificityExpressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific.
    • Involvement in diseaseDefects in CACNA1H are a cause of susceptibility to idiopathic generalized epilepsy type 6 (IGE6) [MIM:611942]. IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. IGE6 is a polygenic and multifactorial disease.
    • Sequence similaritiesBelongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily.
    • DomainEach of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
    • Post-translational
      In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha1 3.2 antibody
      • Alpha13.2 antibody
      • CAC1H_HUMAN antibody
      • CACNA 1H antibody
      • CACNA1 H antibody
      • CACNA1 HB antibody
      • Cacna1h antibody
      • CACNA1HB antibody
      • Calcium channel alpha13.2 subunit antibody
      • Calcium channel voltage dependent T type alpha 1H subunit antibody
      • Calcium channel, voltage-dependent, T type, alpha 1Hb subunit antibody
      • Cav 3.2 antibody
      • Cav T.2 antibody
      • Cav3.2 antibody
      • CavT.2 antibody
      • EIG 6 antibody
      • EIG6 antibody
      • Low voltage activated calcium channel alpha 13.2 subunit antibody
      • Low voltage activated calcium channel alpha1 3.2 subunit antibody
      • Low-voltage-activated calcium channel alpha1 3.2 subunit antibody
      • MNCb 1209 antibody
      • T type Cav3.2 antibody
      • Voltage dependent t type calcium channel alpha 1H subunit antibody
      • Voltage gated calcium channel alpha subunit Cav 3.2 antibody
      • Voltage gated calcium channel alpha subunit Cav T.2 antibody
      • Voltage gated calcium channel alpha subunit Cav3.2 antibody
      • Voltage gated calcium channel alpha subunit CavT.2 antibody
      • Voltage-dependent T-type calcium channel subunit alpha-1H antibody
      • Voltage-gated calcium channel subunit alpha Cav3.2 antibody
      see all

    Anti-CACNA1H antibody [S55-10] images

    • ab84815 staining CACCNA1H in human hippocampal tissue by IHC-P (Bouin's fixed paraffin embedded).

    References for Anti-CACNA1H antibody [S55-10] (ab84815)

    This product has been referenced in:
    • Kürtüncü M  et al. CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). Cephalalgia : (2012). WB ; Human . Read more (PubMed: 23111027) »

    See 1 Publication for this product

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    Both the goat polyclonal anti-mouse IgG (ab97239 and ab98692) should be compatible with the mouse anti-CACNA1H antibody (ab84815) for the experiment you hope to perform. The antib...

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