Overview

  • Product nameAnti-CACNA2D2 antibody
    See all CACNA2D2 primary antibodies
  • Description
    Mouse monoclonal to CACNA2D2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Cow, Rhesus monkey
  • Immunogen

    Recombinant fragment corresponding to the internal amino acids 65-163 (PQQHTMQHWA RRLEQEVDGV MRIFGGVQQL REIYKDNRNL FEVQENEPQK LVEKVAGDIE SLLDRKVQAL KRLADAAENF QKAHRWQDNI KEEDIVYY*) of Human CACNA2D2 (NP_006021) linked to a proprietary tag.

  • Positive control
    • HeLa cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab88486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 130 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionThe alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
  • Tissue specificityPredominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
  • Sequence similaritiesBelongs to the calcium channel subunit alpha-2/delta family.
    Contains 1 cache domain.
    Contains 1 VWFA domain.
  • DomainThe MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • Post-translational
    modifications
    May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
  • Cellular localizationMembrane. Colocalizes with CACNA1A in lipid raft fractions.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha 2 delta calcium channel subunit antibody
    • CA2D2_HUMAN antibody
    • CACNA2D antibody
    • Cacna2d2 antibody
    • Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody
    • Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody
    • Gene 26 antibody
    • KIAA0558 antibody
    • LUAC11.1 antibody
    • Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody
    • Voltage-dependent calcium channel subunit delta-2 antibody
    • Voltage-gated calcium channel subunit alpha-2/delta-2 antibody
    see all

Anti-CACNA2D2 antibody images

References for Anti-CACNA2D2 antibody (ab88486)

ab88486 has not yet been referenced specifically in any publications.

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Thank you for contacting us. Epitope mapping has not been performed for the monoclonal antibodies ab2864 and ab88486. The other antibodies are polyclonals and will bind at many different sites of the protein. Please let me know if I can be of further a...

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