Overview

  • Product name
    Anti-CACNA2D3 antibody
  • Description
    Rabbit polyclonal to CACNA2D3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within the C terminal portion of Human CACNA2D3 (UniProt ID: Q8IZS8), conjugated to KLH.

  • Positive control
    • HepG2 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab102939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 123 kDa.

Target

  • Function
    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).
  • Tissue specificity
    Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed.
  • Sequence similarities
    Belongs to the calcium channel subunit alpha-2/delta family.
    Contains 1 cache domain.
    Contains 1 VWFA domain.
  • Domain
    The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • Post-translational
    modifications
    N-glycosylated.
    May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CA2D3_HUMAN antibody
    • Cacna2d3 antibody
    • Calcium channel alpha2 delta3 subunit antibody
    • Calcium channel voltage dependent alpha 2/delta subunit 3 antibody
    • Calcium channel voltage-dependent alpha 2/delta 3 subunit antibody
    • HSA272268 antibody
    • Voltage dependent calcium channel subunit alpha 2/delta 3 antibody
    • Voltage-dependent calcium channel subunit delta-3 antibody
    • Voltage-gated calcium channel subunit alpha-2/delta-3 antibody
    see all

Images

  • Anti-CACNA2D3 antibody (ab102939) at 1/100 dilution + HepG2 cell lysate at 35 µg

    Predicted band size : 123 kDa

References

ab102939 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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