Overview

  • Product nameAnti-CACNA2D3 antibody
  • Description
    Rabbit polyclonal to CACNA2D3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within the C terminal portion of Human CACNA2D3 (UniProt ID: Q8IZS8), conjugated to KLH.

  • Positive control
    • HepG2 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab102939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 123 kDa.

Target

  • FunctionThe alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).
  • Tissue specificityOnly detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed.
  • Sequence similaritiesBelongs to the calcium channel subunit alpha-2/delta family.
    Contains 1 cache domain.
    Contains 1 VWFA domain.
  • DomainThe MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • Post-translational
    modifications
    N-glycosylated.
    May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CA2D3_HUMAN antibody
    • Cacna2d3 antibody
    • Calcium channel alpha2 delta3 subunit antibody
    • Calcium channel voltage dependent alpha 2/delta subunit 3 antibody
    • Calcium channel voltage-dependent alpha 2/delta 3 subunit antibody
    • HSA272268 antibody
    • Voltage dependent calcium channel subunit alpha 2/delta 3 antibody
    • Voltage-dependent calcium channel subunit delta-3 antibody
    • Voltage-gated calcium channel subunit alpha-2/delta-3 antibody
    see all

Anti-CACNA2D3 antibody images

  • Anti-CACNA2D3 antibody (ab102939) at 1/100 dilution + HepG2 cell lysate at 35 µg

    Predicted band size : 123 kDa

References for Anti-CACNA2D3 antibody (ab102939)

ab102939 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab102939.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"