• Product nameAnti-CACNB2 antibody
    See all CACNB2 primary antibodies
  • Description
    Rabbit polyclonal to CACNB2
  • SpecificityThis antibody recognizes CANB2.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    A region within synthetic peptide: RQETFDSETQ ESRDSAYVEP KEDYSHDHVD HYASHRDHNH RDETHGSSDH, corresponding to amino acids 551-600 of Human CACNB2

  • Positive control
    • HepG2 cell lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products


Our Abpromise guarantee covers the use of ab49131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 69 kDa (predicted molecular weight: 73 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionThe beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • Tissue specificityExpressed in all tissues.
  • Involvement in diseaseDefects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4) [MIM:611876]. BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • Sequence similaritiesBelongs to the calcium channel beta subunit family.
    Contains 1 SH3 domain.
  • Cellular localizationCell membrane > sarcolemma.
  • Information by UniProt
  • Database links
  • Alternative names
    • AW060387 antibody
    • Ca(V) beta 2 antibody
    • CAB2 antibody
    • CACB2_HUMAN antibody
    • CACNB2 antibody
    • CACNLB2 antibody
    • Calcium channel voltage dependent subunit beta 2 antibody
    • Calcium channel voltage-dependent subunit beta 2 antibody
    • Calcium channel, voltage dependent, beta 2 subunit antibody
    • CAVB2 antibody
    • Cavbeta2 antibody
    • Cchb2 antibody
    • FLJ23743 antibody
    • Lambert Eaton Myasthenic syndrome antigen antibody
    • Lambert Eaton myasthenic syndrome antigen B antibody
    • Lambert-Eaton myasthenic syndrome antigen B antibody
    • MGC129334 antibody
    • MGC129335 antibody
    • Myasthenic (Lambert Eaton) syndrome antigen B antibody
    • Myasthenic syndrome antigen B antibody
    • MYSB antibody
    • Voltage dependent L type calcium channel subunit beta 2 antibody
    • Voltage-dependent L-type calcium channel subunit beta-2 antibody
    see all

Anti-CACNB2 antibody images

  • Anti-CACNB2 antibody (ab49131) at 0.5 µg/ml + HepG2 cell lysate at 10 µg with 5% skimmed milk in PBS

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 73 kDa
    Observed band size : 69 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 48 kDa. We are unsure as to the identity of these extra bands.

References for Anti-CACNB2 antibody (ab49131)

ab49131 has not yet been referenced specifically in any publications.

Product Wall

I am sorry to read that you are still having trouble obtaining a good blot for CACNB2. Are you testing the same samples as before, rat brain homogenates? We do not have a blocking peptide for either antibody. For ab93606, you were not obtaining any sig...

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