Overview

  • Product name
  • Description
    Rabbit polyclonal to CACNB3
  • Specificity
    This antibody recognises the beta 3 calcium channel subunit.
  • Tested applications
    Suitable for: WB, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide:

    MYDDSYVPGFEDSEA

    conjugated to KLH, corresponding to amino acids 1-15 of CACNB3.

  • Positive control
    • Rat cortical and hippocampal, neuronal membranes. Negative control: non neuronal cells

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.08% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab16717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 58 kDa.
IP Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution.

Target

  • Function
    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • Tissue specificity
    Expressed mostly in brain, smooth muscle and ovary.
  • Sequence similarities
    Belongs to the calcium channel beta subunit family.
    Contains 1 SH3 domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAB3 antibody
    • CACB3_HUMAN antibody
    • Cacnb3 antibody
    • CACNLB3 antibody
    • Calcium channel voltage dependent beta 3 subunit antibody
    • Calcium channel voltage-dependent subunit beta 3 antibody
    • FLJ58949 antibody
    • Voltage-dependent L-type calcium channel subunit beta-3 antibody
    see all

Anti-CACNB3 antibody images



  • Predicted band size : 58 kDa

    Image from Uriu Y et al, J Biol Chem. 2010 Jul 9;285(28):21750-67. Epub 2010 May 7, Fig 7. DOI 10.1074/jbc.M110.101311

References for Anti-CACNB3 antibody (ab16717)

This product has been referenced in:
  • Uriu Y  et al. Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. J Biol Chem 285:21750-67 (2010). WB ; Human . Read more (PubMed: 20452978) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Western blot
Sample
Rat Recombinant protein (recombinant protein from e.Coli)
Loading amount
10 µg
Specification
recombinant protein from e.Coli
Gel Running Conditions
Reduced Denaturing
Blocking step
Milk as blocking agent for 15 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C
Username

Abcam user community

Verified customer

Submitted Oct 23 2008

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up