Overview

  • Product name
  • Description
    Goat polyclonal to CACNB4
  • Specificity
    This antibody is expected to recognise all three reported isoforms.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Pig, Chinese hamster
  • Immunogen

    Synthetic peptide:

    C-DYPDSYQDTYKPH

    , corresponding to near C terminal amino acids 491-503 of Human CACNB4

  • Positive control
    • Human Bone Marrow lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1:4,000.
    WB: Use at a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
    • Tissue specificity
      Expressed predominantly in the cerebellum and kidney.
    • Involvement in disease
      Genetic variations in CACNB4 are the cause of susceptibility to idiopathic generalized epilepsy type 9 (IGE9) [MIM:607682]. IGE9 is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
      Genetic variations in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682]. EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
    • Sequence similarities
      Belongs to the calcium channel beta subunit family.
      Contains 1 SH3 domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAB4 antibody
      • CACB4_HUMAN antibody
      • Cacnb4 antibody
      • CACNLB4 antibody
      • Calcium channel voltage dependent beta 4 subunit antibody
      • Calcium channel voltage dependent subunit beta 4 antibody
      • Calcium channel voltage-dependent subunit beta 4 antibody
      • Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody
      • EA5 antibody
      • EIG9 antibody
      • EJM antibody
      • EJM4 antibody
      • EJM6 antibody
      • Voltage-dependent L-type calcium channel subunit beta-4 antibody
      see all

    Anti-CACNB4 antibody images

    • Anti-CACNB4 antibody (ab58601) at 0.2 µg/ml + Human Bone Marrow lysate at 35 µg

      Predicted band size : 58 kDa
      Observed band size : 58 kDa

    References for Anti-CACNB4 antibody (ab58601)

    ab58601 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58601.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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