Overview

  • Product nameCAD peptide

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab8432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

    Western blot

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • Aspartate carbamoyltransferase
    • Aspartate transcarbamylase
    • CAD protein
    • CAD trifunctional protein
    • Carbamoyl phosphate synthetase 2
    • CPSase ATCase DHOase
    • Dihydroorotase
    • Glutamine dependent carbamoyl phosphate synthase
    • Multifunctional protein CAD
    see all
  • RelevanceCarbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis. This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway. Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus. While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD.
  • Cellular localizationCytoplasmic and Nuclear

References for CAD peptide (ab8432)

ab8432 has not yet been referenced specifically in any publications.

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