Overview

  • Product nameAnti-CADPS2 antibody
  • Description
    Rabbit polyclonal to CADPS2
  • Specificityspecific to CADPS2 and does not recognize CADPS1
  • Tested applicationsSuitable for: ICC/IF, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    19 amino acid peptide near the center of the human CADPS2

  • Positive control
    • Human brain cytoplasmic lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab69794 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 147 kDa (predicted molecular weight: 147 kDa).

Target

  • RelevanceCADPS2 (Ca2+-dependent activator protein for secretion) belongs to the CAPS/Cadps family and consists of two members, CAPS1 and CAPS2. Both members play an important role in secretory granule exocytosis. CADPS2 is involved in the release of two neurotrophins, brain-derived neurotrophic factor and neurotrophin-3, from parallel fibers of cerebellar granule cells. CAPS proteins are expressed predominantly in the brain. CADPS2 has been found in various brain regions including the olfactory bulb, cerebrum, hippocampal formation, thalamus, mesencephalic tegmentum, cerebellum, medulla and spinal cord. CADPS2 colocalizes with proteins related to exocytosis (VAMP and SNAP-25) and endocytosis (Dynamin I) in the cell soma and processes of the mesencephalic tegmentum and cerebellum.
  • Cellular localizationCytoplasmic. Membrane-associated to vesicles.
  • Database links
  • Alternative names
    • Cadps2 antibody
    • Calcium-dependent activator protein for secretion 2 antibody
    • Calcium-dependent secretion activator 2 antibody
    • CAPS2 antibody
    • KIAA1591 antibody
    see all

Anti-CADPS2 antibody images

  • Lane 1 : Anti-CADPS2 antibody (ab69794) at 0.5 µg/ml
    Lane 2 : Anti-CADPS2 antibody (ab69794) at 1 µg/ml

    Lane 1 : Human brain tissue lysate
    Lane 2 : Human brain tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 147 kDa
    Observed band size : 148 kDa (why is the actual band size different from the predicted?)
  • ab69794 at 5 µg/ml staining CADPS2 in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

  • Immunofluorescence of CAPS2 in Human Brain cells using ab69794 at 20 ug/ml.

References for Anti-CADPS2 antibody (ab69794)

ab69794 has not yet been referenced specifically in any publications.

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