Overview

  • Product name
    Caffeic acid
  • Description
    Specific NF-κB inhibitor
  • Biological description
    Specific NF-κB inhibitor (IC50 = 8.8 μM). Antioxidant, immunomodulatory and anti-inflammatory effects in vitro and in vivo. Additionally inhibits HDAC (IC50 = 0.85 mM). Blood-brain barrier permeable.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Tsai SJ  et al. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. Eur J Pharmacol 670:441-7 (2011). Read more (PubMed: 21970803) »
  • Mori H & Iwahashi H Antioxidant Activity of Caffeic Acid through a Novel Mechanism under UVA Irradiation. J Clin Biochem Nutr 45:49-55 (2009). Read more (PubMed: 19590707) »
  • Waldecker M  et al. Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J Nutr Biochem 19:587-93 (2008). Read more (PubMed: 18061431) »
  • Fitzpatrick LR  et al. Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappaB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J Pharmacol Exp Ther 299:915-20 (2001). Read more (PubMed: 11714876) »

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