Anti-Calcium channel L type DHPR alpha 2 subunit antibody (ab62814)

Overview

  • Product name
    Anti-Calcium channel L type DHPR alpha 2 subunit antibody
    See all Calcium channel L type DHPR alpha 2 subunit primary antibodies
  • Description
    Goat polyclonal to Calcium channel L type DHPR alpha 2 subunit
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Cow, Dog, PigDoes not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    C-QEIFNKYNKDKKVR

    , corresponding to internal sequence amino acids 370-383 of Human Calcium channel L type DHPR alpha 2 subunit

  • Positive control
    • Human Brain (Cerebellum) lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab62814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: 1/16000.
    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 140 kDa (predicted molecular weight: 123 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
    • Tissue specificity
      Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
    • Sequence similarities
      Belongs to the calcium channel subunit alpha-2/delta family.
      Contains 1 cache domain.
      Contains 1 VWFA domain.
    • Domain
      The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
    • Post-translational
      modifications
      Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CA2D1_HUMAN antibody
      • CACN A2 antibody
      • CACNA2 antibody
      • Cacna2d1 antibody
      • CACNL2A antibody
      • Calcium channel L type alpha 2 polypeptide antibody
      • Calcium channel voltage dependent alpha 2/delta subunit 1 antibody
      • CCHL2A antibody
      • Dihydropyridine receptor alpha 2 subunit antibody
      • Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit antibody
      • Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta antibody
      • L type calcium channel subunit alpha 2 antibody
      • MHS 3 antibody
      • MHS3 antibody
      • Voltage dependent calcium channel subunit alpha 2/delta 1 antibody
      • Voltage gated calcium channel subunit alpha 2/delta 1 antibody
      • Voltage-dependent calcium channel subunit delta-1 antibody
      • Voltage-gated calcium channel subunit alpha-2/delta-1 antibody
      see all

    Anti-Calcium channel L type DHPR alpha 2 subunit antibody images

    • Anti-Calcium channel L type DHPR alpha 2 subunit antibody (ab62814) at 0.03 µg/ml + Human Brain (Cerebellum) lysate (in RIPA buffer) at 35 µg

      Predicted band size : 123 kDa
      Observed band size : 140 kDa (why is the actual band size different from the predicted?)

    References for Anti-Calcium channel L type DHPR alpha 2 subunit antibody (ab62814)

    This product has been referenced in:
    • Lugenbiel P  et al. Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. PLoS One 10:e0116395 (2015). WB . Read more (PubMed: 25775120) »

    See 1 Publication for this product

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