The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 20 µg/ml.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 38 kDa.
Use a concentration of 5 µg/ml.
FunctionMay be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.
Tissue specificityPredominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.
Sequence similaritiesBelongs to the FAM26 family.
Cellular localizationCell membrane. Endoplasmic reticulum membrane. Colocalizes with HSPA5 at the endoplasmic reticulum.