Overview

  • Product name
  • Description
    Rabbit polyclonal to CALHM1
  • Specificity
    This antibody is predicted to not crossreact with CALHM2 or CALHM3.
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 17 amino acids near the amino terminus of Human CALHM1 (NP_001001412).

  • Positive control
    • Rat liver tissue lysate; Rat liver tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab106561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 38 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function
    May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.
  • Tissue specificity
    Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.
  • Sequence similarities
    Belongs to the FAM26 family.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane. Colocalizes with HSPA5 at the endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAHM1_HUMAN antibody
    • Calcium homeostasis modulator 1 antibody
    • Calcium homeostasis modulator protein 1 antibody
    • CALHM1 antibody
    • FAM26C antibody
    • Family with sequence similarity 26, member C antibody
    • MGC39514 antibody
    • MGC39617 antibody
    • OTTHUMP00000020413 antibody
    • Protein FAM26C antibody
    see all

Images

  • Lane 1 : Anti-CALHM1 antibody (ab106561) at 1 µg/ml
    Lane 2 : Anti-CALHM1 antibody (ab106561) at 2 µg/ml

    Lane 1 : Rat liver tissue lysate
    Lane 2 : Rat liver tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 38 kDa
  • Immunohistochemical analysis of CALHM1 in paraffin embedded Rat liver tissue, using ab106561 at 5 µg/ml.
  • Immunofluorescence of CALHM1 in Rat Liver cells using ab106561 at 20 ug/ml.

References

ab106561 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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