• Product nameAnti-Calreticulin 3 antibody
    See all Calreticulin 3 primary antibodies
  • Description
    Rabbit polyclonal to Calreticulin 3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (RWLQSTNDSR FGHFRLSSGK FYGHKEKDKG LQTTQNGRFY AISARFKPFS) of Human Calreticulin 3 (NP_659483).

  • Positive control
    • Jurkat cell lysate.



Our Abpromise guarantee covers the use of ab87139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionDuring spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
  • Tissue specificityTestis specific.
  • Involvement in diseaseDefects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19) [MIM:613875]. CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similaritiesBelongs to the calreticulin family.
  • DomainCan be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
    The interaction with glycans occurs through a binding site in the globular lectin domain.
    The zinc binding sites are localized to the N-domain.
  • Cellular localizationEndoplasmic reticulum lumen.
  • Information by UniProt
  • Database links
  • Alternative names
    • CALR 3 antibody
    • CALR3 antibody
    • CALR3_HUMAN antibody
    • Calreticulin 2 antibody
    • Calreticulin-2 antibody
    • Calreticulin-3 antibody
    • Calreticulin2 antibody
    • Calreticulin3 antibody
    • Calsperin antibody
    • Cancer/testis antigen 93 antibody
    • CMH19 antibody
    • CRT2 antibody
    • CT93 antibody
    • FLJ25355 antibody
    • MGC26577 antibody
    see all

Anti-Calreticulin 3 antibody images

  • Anti-Calreticulin 3 antibody (ab87139) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)

References for Anti-Calreticulin 3 antibody (ab87139)

ab87139 has not yet been referenced specifically in any publications.

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