The antibody is suitable for the detection of Calretinin in neurons and may be used as an aid in differential diagnosis of pleura-mesothelioma. This marker is frequently expressed in epitheloid mesothelioma, while occasionally it turns positive in sarcomatous mesothelioma and carcinoma. It was found to be negative in sarcoma and in 90% of adenocarcinoma.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Calretinin is a calcium-binding protein which is abundant in auditory neurons.
Belongs to the calbindin family. Contains 6 EF-hand domains.