Overview

  • Product nameAnti-Calsequestrin 2 antibody
    See all Calsequestrin 2 primary antibodies
  • Description
    Mouse monoclonal to Calsequestrin 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 20-400 of Human Calsequestrin 2

Properties

Applications

Our Abpromise guarantee covers the use of ab54858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCalsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium.
    • Involvement in diseaseDefects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:611938]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
    • Sequence similaritiesBelongs to the calsequestrin family.
    • Cellular localizationSarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • AA033488 antibody
      • AW146219 antibody
      • Calsequestrin 2 (cardiac muscle) antibody
      • Calsequestrin 2 fast twitch cardiac muscle antibody
      • Calsequestrin antibody
      • Calsequestrin cardiac muscle isoform antibody
      • Calsequestrin fast twitch cardiac muscle antibody
      • Calsequestrin-2 antibody
      • Calsequestrin2 antibody
      • cardCSQ antibody
      • Cardiac calsequestrin 2 antibody
      • cardiac muscle isoform antibody
      • CASQ 2 antibody
      • CASQ2 antibody
      • CASQ2_HUMAN antibody
      • cCSQ antibody
      • ESTM52 antibody
      • FLJ26321 antibody
      • FLJ93514 antibody
      • PDIB2 antibody
      see all

    Anti-Calsequestrin 2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab54858 Calsequestrin 2 antibody at 1ug/ml. Predicted band size of immunogen is 68 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    References for Anti-Calsequestrin 2 antibody (ab54858)

    ab54858 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"