Overview

  • Product nameAnti-Calsequestrin 2 antibody
    See all Calsequestrin 2 primary antibodies
  • Description
    Rabbit polyclonal to Calsequestrin 2
  • SpecificityThis antibody reacts with Calsequestrin 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Cow, Dog, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Mouse Calsequestrin 2 aa 57-74 conjugated to keyhole limpet haemocyanin.
    Sequence:

    LYYHEPVSSDKVSQKQFQLKE

  • Positive control
    • Extract of rat cardiac muscle (S1 fraction); HEK-293T cells

Properties

Applications

Our Abpromise guarantee covers the use of ab62662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa).

Used at a concentration of 0.5 - 1.0 µg/ml using HEK-293T cells expressing human calsequestrin-2 and extract of rat cardiac muscle (S1 fraction). Staining of the calsequestrin-2 band is specifically inhibited by the immunizing peptide.

Target

  • FunctionCalsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium.
  • Involvement in diseaseDefects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:611938]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
  • Sequence similaritiesBelongs to the calsequestrin family.
  • Cellular localizationSarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA033488 antibody
    • AW146219 antibody
    • Calsequestrin 2 (cardiac muscle) antibody
    • Calsequestrin 2 fast twitch cardiac muscle antibody
    • Calsequestrin antibody
    • Calsequestrin cardiac muscle isoform antibody
    • Calsequestrin fast twitch cardiac muscle antibody
    • Calsequestrin-2 antibody
    • Calsequestrin2 antibody
    • cardCSQ antibody
    • Cardiac calsequestrin 2 antibody
    • cardiac muscle isoform antibody
    • CASQ 2 antibody
    • CASQ2 antibody
    • CASQ2_HUMAN antibody
    • cCSQ antibody
    • ESTM52 antibody
    • FLJ26321 antibody
    • FLJ93514 antibody
    • PDIB2 antibody
    see all

References for Anti-Calsequestrin 2 antibody (ab62662)

This product has been referenced in:
  • Patel BB  et al. Lifelong exposure to bisphenol a alters cardiac structure/function, protein expression, and DNA methylation in adult mice. Toxicol Sci 133:174-85 (2013). Mouse . Read more (PubMed: 23418087) »
  • Calvé A  et al. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol 302:H2048-57 (2012). Read more (PubMed: 22447943) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab62662.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"