Overview

  • Product name
    Anti-Calsequestrin 2 antibody
    See all Calsequestrin 2 primary antibodies
  • Description
    Rabbit polyclonal to Calsequestrin 2
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 124-398 of Human Calsequestrin 2.

  • Positive control
    • H1299 cells lysate and Cal27 xenograft

Properties

Applications

Our Abpromise guarantee covers the use of ab96387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Antigen retrieval is not essential but may optimise staining.
WB 1/500 - 1/3000. Predicted molecular weight: 46 kDa.

Target

  • Function
    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium.
  • Involvement in disease
    Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:611938]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
  • Sequence similarities
    Belongs to the calsequestrin family.
  • Cellular localization
    Sarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA033488 antibody
    • AW146219 antibody
    • Calsequestrin 2 (cardiac muscle) antibody
    • Calsequestrin 2 fast twitch cardiac muscle antibody
    • Calsequestrin antibody
    • Calsequestrin cardiac muscle isoform antibody
    • Calsequestrin fast twitch cardiac muscle antibody
    • Calsequestrin-2 antibody
    • Calsequestrin2 antibody
    • cardCSQ antibody
    • Cardiac calsequestrin 2 antibody
    • cardiac muscle isoform antibody
    • CASQ 2 antibody
    • CASQ2 antibody
    • CASQ2_HUMAN antibody
    • cCSQ antibody
    • ESTM52 antibody
    • FLJ26321 antibody
    • FLJ93514 antibody
    • PDIB2 antibody
    see all

Images

  • Anti-Calsequestrin 2 antibody (ab96387) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 46 kDa
  • Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using ab96387 at 1:500 dilution.

References

ab96387 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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