Overview

  • Product nameAnti-Calsequestrin 2 antibody [EPR4227]
    See all Calsequestrin 2 primary antibodies
  • Description
    Rabbit monoclonal [EPR4227] to Calsequestrin 2
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human Calsequestrin 2

  • Positive control
    • Human heart, mouse heart or rat heart lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Applications

Our Abpromise guarantee covers the use of ab108289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 55 kDa (predicted molecular weight: 46 kDa).
  • Application notesIs unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • FunctionCalsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium.
    • Involvement in diseaseDefects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:611938]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
    • Sequence similaritiesBelongs to the calsequestrin family.
    • Cellular localizationSarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • AA033488 antibody
      • AW146219 antibody
      • Calsequestrin 2 (cardiac muscle) antibody
      • Calsequestrin 2 fast twitch cardiac muscle antibody
      • Calsequestrin antibody
      • Calsequestrin cardiac muscle isoform antibody
      • Calsequestrin fast twitch cardiac muscle antibody
      • Calsequestrin-2 antibody
      • Calsequestrin2 antibody
      • cardCSQ antibody
      • Cardiac calsequestrin 2 antibody
      • cardiac muscle isoform antibody
      • CASQ 2 antibody
      • CASQ2 antibody
      • CASQ2_HUMAN antibody
      • cCSQ antibody
      • ESTM52 antibody
      • FLJ26321 antibody
      • FLJ93514 antibody
      • PDIB2 antibody
      see all

    Anti-Calsequestrin 2 antibody [EPR4227] images

    • All lanes : Anti-Calsequestrin 2 antibody [EPR4227] (ab108289) at 1/1000 dilution

      Lane 1 : Human heart cell lysate
      Lane 2 : Mouse heart lysate
      Lane 3 : Rat heart lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 46 kDa
      Observed band size : 55 kDa (why is the actual band size different from the predicted?)

    References for Anti-Calsequestrin 2 antibody [EPR4227] (ab108289)

    This product has been referenced in:
    • Curran J  et al. EHD3-dependent endosome pathway regulates cardiac membrane excitability and physiology. Circ Res 115:68-78 (2014). Read more (PubMed: 24759929) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"