Anti-Calsequestrin 2 antibody [EPR4228] (ab108381)


  • Product nameAnti-Calsequestrin 2 antibody [EPR4228]
    See all Calsequestrin 2 primary antibodies
  • Description
    Rabbit monoclonal [EPR4228] to Calsequestrin 2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human Calsequestrin 2.

  • Positive control
    • Human heart and Human skeletal muscle lysates, Human cardiac muscles and Human skeletal muscles tissues
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab108381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 55 kDa (predicted molecular weight: 46 kDa).
IHC-P 1/100 - 1/250. Perform antigen retrieval before commencing with IHC staining protocol.
  • Application notesIs unsuitable for Flow Cyt,ICC or IP.
  • Target

    • FunctionCalsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium.
    • Involvement in diseaseDefects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:611938]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
    • Sequence similaritiesBelongs to the calsequestrin family.
    • Cellular localizationSarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • AA033488 antibody
      • AW146219 antibody
      • Calsequestrin 2 (cardiac muscle) antibody
      • Calsequestrin 2 fast twitch cardiac muscle antibody
      • Calsequestrin antibody
      • Calsequestrin cardiac muscle isoform antibody
      • Calsequestrin fast twitch cardiac muscle antibody
      • Calsequestrin-2 antibody
      • Calsequestrin2 antibody
      • cardCSQ antibody
      • Cardiac calsequestrin 2 antibody
      • cardiac muscle isoform antibody
      • CASQ 2 antibody
      • CASQ2 antibody
      • CASQ2_HUMAN antibody
      • cCSQ antibody
      • ESTM52 antibody
      • FLJ26321 antibody
      • FLJ93514 antibody
      • PDIB2 antibody
      see all

    Anti-Calsequestrin 2 antibody [EPR4228] images

    • Immunohistochemical analysis of paraffin-embedded Human skeletal muscles using ab108381 at a dilution of 1/100.
    • All lanes : Anti-Calsequestrin 2 antibody [EPR4228] (ab108381) at 1/1000 dilution

      Lane 1 : Human heart lysate
      Lane 2 : Human skeletal muscle lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 46 kDa
      Observed band size : 55 kDa (why is the actual band size different from the predicted?)
    • Immunohistochemical analysis of paraffin-embedded Human cardiac muscles using ab108381 at a dilution of 1/100.
    • ab108381 showing negative staining in Normal brain tissue.

    • ab108381 showing negative staining in Normal breast tissue.

    • ab108381 showing negative staining in Normal kidney tissue.

    • ab108381 showing negative staining in Normal colon tissue.

    • ab108381 showing negative staining in Normal tonsil tissue.

    References for Anti-Calsequestrin 2 antibody [EPR4228] (ab108381)

    ab108381 has not yet been referenced specifically in any publications.

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