• Product nameAnti-CaMKI antibody
    See all CaMKI primary antibodies
  • Description
    Rabbit polyclonal to CaMKI
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic non-phosphopeptide derived from human CaMKI around the phosphorylation site of threonine 177 (L-S-TP-A-C).

  • Positive control
    • Human breast carcinoma tissue.



Our Abpromise guarantee covers the use of ab62683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
IHC-P 1/50 - 1/100.


  • FunctionCalcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
  • Tissue specificityWidely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.
  • DomainThe autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Post-translational
    Phosphorylated by CaMKK1 and CaMKK2 on Thr-177.
    Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation.
  • Cellular localizationCytoplasm. Nucleus. Predominantly cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcium / calmodulin dependent protein kinase 1 antibody
    • Calcium / calmodulin dependent protein kinase I antibody
    • Calcium / calmodulin dependent protein kinase type 1 antibody
    • Calcium/calmodulin dependent protein kinase 1 antibody
    • Calcium/calmodulin dependent protein kinase I antibody
    • Calcium/calmodulin dependent protein kinase type 1 antibody
    • Calcium/calmodulin-dependent protein kinase type 1 antibody
    • CaM K1 antibody
    • CaM KI antibody
    • CaM kinase 1 alpha antibody
    • CAM kinase 1 antibody
    • CaM kinase I alpha antibody
    • CaM kinase I antibody
    • CaM-KI antibody
    • CaMK 1 antibody
    • CAMK I antibody
    • CaMK1 alpha antibody
    • CAMK1 antibody
    • CAMK1 PEN antibody
    • CaMKI alpha antibody
    • CaMKI-alpha antibody
    • KCC1A_HUMAN antibody
    • MGC120317 antibody
    • MGC120318 antibody
    see all

Anti-CaMKI antibody images

  • ab62683 at 1/50 - 1/100 dilution staining CaMKI in human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

References for Anti-CaMKI antibody (ab62683)

ab62683 has not yet been referenced specifically in any publications.

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