Overview

  • Product nameAnti-CaMKK antibody - N-terminal
    See all CaMKK primary antibodies
  • Description
    Rabbit polyclonal to CaMKK - N-terminal
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the N terminal region of human CaMKK

  • Positive control
    • Mouse cerebellum tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab76534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
ELISA 1/1000.

Target

  • FunctionCalcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • DomainThe autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
    The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
  • Post-translational
    modifications
    Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ca2+/calmodulin-dependent protein kinase kinase alpha antibody
    • Calcium/calmodulin dependent protein kinase kinase antibody
    • Calcium/calmodulin dependent protein kinase kinase 1 alpha antibody
    • Calcium/calmodulin dependent protein kinase kinase 1 antibody
    • Calcium/calmodulin dependent protein kinase kinase alpha antibody
    • Calcium/calmodulin-dependent protein kinase kinase 1 antibody
    • Calcium/calmodulin-dependent protein kinase kinase alpha antibody
    • CaM kinase kinase alpha antibody
    • CaM-kinase IV kinase antibody
    • CaM-kinase kinase 1 antibody
    • CaM-kinase kinase alpha antibody
    • CaM-KK 1 antibody
    • CaM-KK alpha antibody
    • CaMKK 1 antibody
    • CaMKK alpha antibody
    • CAMKK alpha protein antibody
    • CaMKK antibody
    • Camkk1 antibody
    • CAMKKA antibody
    • DKFZp761M0423 antibody
    • KKCC1_HUMAN antibody
    • MGC34095 antibody
    • OTTMUSP00000006419 antibody
    see all

Anti-CaMKK antibody - N-terminal images

  • Anti-CaMKK antibody - N-terminal (ab76534) at 1/50 dilution + mouse cerebellum tissue lysates at 35 µg

    Predicted band size : 56 kDa
    Observed band size : 56 kDa

References for Anti-CaMKK antibody - N-terminal (ab76534)

ab76534 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab76534.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"