Overview

  • Product nameAnti-CaMKK antibody, prediluted
    See all CaMKK primary antibodies
  • Description
    Rabbit polyclonal to CaMKK, prediluted
  • SpecificityThis antibody reacts with CaMKK alpha.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    GEGGKSPELPGVQEDEAAS

    , corresponding to amino acids 487-505 of Human CaMKK alpha, [Swiss Prot Q8N5S9]

  • Positive control
    • Human brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab53902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Ready-to-use for 30 min at RT.
    Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCalcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
    • Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
      Contains 1 protein kinase domain.
    • DomainThe autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
      The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
    • Post-translational
      modifications
      Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.
    • Cellular localizationCytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Ca2+/calmodulin-dependent protein kinase kinase alpha antibody
      • Calcium/calmodulin dependent protein kinase kinase antibody
      • Calcium/calmodulin dependent protein kinase kinase 1 alpha antibody
      • Calcium/calmodulin dependent protein kinase kinase 1 antibody
      • Calcium/calmodulin dependent protein kinase kinase alpha antibody
      • Calcium/calmodulin-dependent protein kinase kinase 1 antibody
      • Calcium/calmodulin-dependent protein kinase kinase alpha antibody
      • CaM kinase kinase alpha antibody
      • CaM-kinase IV kinase antibody
      • CaM-kinase kinase 1 antibody
      • CaM-kinase kinase alpha antibody
      • CaM-KK 1 antibody
      • CaM-KK alpha antibody
      • CaMKK 1 antibody
      • CaMKK alpha antibody
      • CAMKK alpha protein antibody
      • CaMKK antibody
      • Camkk1 antibody
      • CAMKKA antibody
      • DKFZp761M0423 antibody
      • KKCC1_HUMAN antibody
      • MGC34095 antibody
      • OTTMUSP00000006419 antibody
      see all

    Anti-CaMKK antibody, prediluted images

    • Human brain stained with neat ab53902

    References for Anti-CaMKK antibody, prediluted (ab53902)

    ab53902 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab53902.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"