All tags p53 Cellular responses of p53

Cellular responses of p53

A complete range of tools to advance your research on p53 and its cellular responses. 

The tumor suppressor gene, p53, responds to a range of cellular stresses by functioning as both a transcription factor and inhibitor. Here we discuss the main cellular responses and suggest products for the protein targets involved. 

Figure 1: Shows cellular responses mediated by p53 and the protein targets involved. Adapted from doi.org/10.3389/fonc.2014.00285. 

Cell cycle arrest and p53

p53 can inhibit cell cycle progression in multiple ways: by the upregulation of p21, which in turn inhibits members of the cyclin dependent kinase family, or by the transcriptional regulation of Gadd45 and 14-3-3σ expression.

To explore the different p53 responsive proteins that facilitate cell cycle arrest please see our products below.


TargetAntibodyInhibitorProtein
p21Anti-p21 antibody [EPR362] 
Sorafenib Recombinant Human p21 protein
CDK1Anti-CDK1 antibody [EPR165]Ro 3306 Recombinant human CDK1 + CCNB1 protein 
CDK2Anti-Cdk2 antibody [E304] SC 221409 Recombinant human CDK2 + CCNE1 protein 
CDK3Anti-Cdk3 antibody pan kinase: 10Z-Hymenialdisine Recombinant Human Cdk3 protein
CDK4Anti-Cdk4 antibody [EPR4513-32-7] Fascaplysin Recombinant Human Cdk4 protein 
CDK6Anti-Cdk6 antibody [EPR4515] PD0332991 Recombinant human CDK6 + CCND1 protein
14-3-3σAnti-14-3-3 sigma antibody [EPR5873(2)] -Recombinant Human 14-3-3 sigma protein

Click here for more cell cycle resources

DNA repair and p53

p53 plays a role in DNA repair to maintain genomic stability in response to low stress conditions. It can do this via the activation of Gadd45 and p53R2.

To explore these p53 responsive proteins and their role in DNA repair please see our products below.


TargetAntibodyProteinInhibitor
Gadd45Anti-GADD45A antibodyRecombinant Human GADD45A protein SP600125 
Anti-GADD45B antibody Recombinant Human GADD45B protein 
p53R2Anti-p53R2 antibody [EPR8816]  Recombinant Human p53R2 protein 


Angiogenesis and p53

p53 plays a key role in preventing the process of angiogenesis taking place by stimulating the production of a number of genes and inhibiting others. This includes stimulating Tsp1 and BAI1, anti-angiogenic factors; and inhibiting VEGF, a pro-angiogenic factor.

To explore these p53 responsive proteins and their role preventing angiogenesis please see our products below. 


TargetAntibodyInhibitorProteinKit
VEGFMouse monoclonal [VG-1] to VEGFA VEGF R2: ZM306416 hydrochloride Recombinant human VEGF 165A protein (Biotin) Human VEGF ELISA Kit 
Tsp1

Anti-Thrombos
-pondin antibody [A6.1] 

LSKL
(coming soon)
Natural Human Thrombos-pondin protein Human Thrombos-pondin 1 ELISA Kit 
BAI1Anti-BAI1 antibody -Human BAI1 associated protein 2 isoform 3 peptide -
Target    Antibody    Inhibitor    Protein    Kit
VEGF    Mouse monoclonal [VG-1] to VEGFA (ab1316)    VEGF R2: ZM306416 hydrochloride (ab144576)    Recombinant human VEGF 165A protein (Biotin) (ab168684)    Human VEGF ELISA Kit (ab100663)
Tsp1    Anti-Thrombospondin antibody [A6.1] (ab1823)    LSKL    Natural Human Thrombospondin protein (ab62261)    Human Thrombospondin 1 ELISA Kit (ab193716)
                
BAI1    Anti-BAI1 antibody (ab135907)    -    Human BAI1 associated protein 2 isoform 3 peptide (ab19041)    -


Apoptosis and p53

p53 stimulates a wide network of signals that act through the extrinsic and intrinsic apoptosis pathways. The extrinsic pathway involves activation of ‘death’ receptors, which leads to the activation of apoptosis- inducing caspases.  The intrinsic apoptotic pathway is dominated by the Bcl-2 family of proteins, which also trigger cell death via the common execution caspase cascade.

To explore these p53 responsive proteins and their role in inducing apoptosis please see our products below.

TargetAntibodyProteinKitInhibitor
DR5Anti-DR5 antibody [EPR1659(2)] Recombinant Human DR5 protein Human DR5 ELISA Kit (CD262)Bioymifi
FasAnti-Fas antibody [EPR5700] Recombinant Human Fas Ligand protein Human Fas Ligand ELISA Kit (APTL) -
Bcl-2Anti-Bcl-2 antibody [E17] Recombinant Human Bcl-2 proteinHuman Bcl-2 ELISA Kit  Venetoclax ABT -199 
BaxAnti-Bax antibody [E63] Recombinant Human Bax protein Human Bax ELISA Kit BAM7 


Senescence and p53

As an alternative to apoptosis, p53 can induce senescence in response to high levels of stress, thought to be mediated by p53 targets p21 and plasminogen activator inhibitor 1 (PAI-1).

To explore these p53 responsive proteins and their role in senescence please see our products below.


 AntibodyInhibitorProteinKit
PAI-1Anti-PAI1 antibody [EPR17795] 

Plasminogen Activator Inhibitor 1 

Recombinant human PAI1 protein Human PAI1 ELISA Kit 
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