Anti-Cannabinoid Receptor II antibody (ab77265)

Overview

  • Product name
    Anti-Cannabinoid Receptor II antibody
    See all Cannabinoid Receptor II primary antibodies
  • Description
    Goat polyclonal to Cannabinoid Receptor II
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Chimpanzee, Rhesus monkey
  • Immunogen

    Synthetic peptide:

    C-TETEADGKITPWPD

    , corresponding to C terminal amino acids 338-351 of Human Cannabinoid Receptor II (NP_001832.1).

  • Positive control
    • Human T-cell line Jurkat cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab77265 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunising peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab77265 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: Antibody detection limit dilution 1/16000.
    WB: Use at a concentration of 2 - 3 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 40 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
    • Tissue specificity
      Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).
    • Sequence similarities
      Belongs to the G-protein coupled receptor 1 family.
    • Post-translational
      modifications
      Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
    • Cellular localization
      Cell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cannabinoid receptor 2 antibody
      • Cannabinoid receptor 2 macrophage antibody
      • CB 2 antibody
      • CB-2 antibody
      • CB2 antibody
      • CNR2 antibody
      • CNR2_HUMAN antibody
      • CNRII antibody
      • CX 5 antibody
      • CX5 antibody
      • hCB2 antibody
      • testis-dominant CNR2 isoform CB2 antibody
      see all

    Images

    References

    ab77265 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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