Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Use a concentration of 1 µg/ml. Preliminary experiments in human tonsil, thymus and peripheral mononucleocytes lysates gave no specific signal but low background.
Use at an assay dependent dilution. For peptide ELISA: antibody detection limit dilution 1/128000.
FunctionInhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Tissue specificityMost abundant in spleen and peripheral blood leukocytes.